Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol

Abstract

Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti‐in‐ flammatory and anti‐anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell‐shaped dose‐response was observed, which limits its clinical use. In the present study, we have studied in mice the anti‐inflammatory and anti‐nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti‐inflammatory and anti‐nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan‐induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti‐inflammatory action that may contribute to overcoming the bell‐shaped dose‐response of purified CBD. We therefore propose that Cannabis clone 202 (Avi‐ dekel) extract is superior over CBD for the treatment of inflammatory conditions.

1. Introduction

Inflammation and pain have accompanied human life for ages. Many anti-inflammation and anti-pain medications and various approaches have been employed through the centuries and in recent time. Many of used drugs, however, impose severe side effects. Cannabis from various origins and species has been employed in various forms as anti-pain agents for thousands of years [1]-[3]. One example is the legitimated drug Sativex® (Nabiximols) that is used in the treatment of severe spasticity in patients with multiple sclerosis [4]. Two other drugs, Marinol (Dronabinol) and Cesamet, have been approved for use in cancer-related anorexia-cachexia syndrome as well as for nausea and vomiting [3]. But a major disadvantage of Cannabis phytomedicine is its psychoactive effects due to the presence of 9 -Tetrahydrocannabinol (THC).

Reference the complete article at: http://file.scirp.org/pdf/PP_2015021016351567.pdf

by Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš

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